Zoals je in de lijst hieronder kunt zien, zitten er flink wat bekende bands bij, zoals Iron Maiden, Blink 182, Queens of the Stone Age, The Police, Blur, Coldplay etc. Net zoals in Guitar Hero: World Tour kun je deze nummers spelen met gitaar, basgitaar, drumstel en microfoon.
- 3 Doors Down - “Kryptonite”
- A Perfect Circle - “Judith”
- AFI - “Medicate”
- Arctic Monkeys - “Brianstorm”
- Attack! Attack! UK - “You And Me”
- Band Of Horses - “Cigarettes, Wedding Bands”
- Beastie Boys - “Gratitude”
- Beck - “Gamma Ray”
- Billy Idol - “Dancing With Myself”
- Billy Squier - “Lonely Is The Night”
- Blink-182 - “The Rock Show”
- Blur - “Song 2”
- Bob Dylan - “All Along The Watchtower”
- Bon Jovi - “You Give Love A Bad Name”
- Brand New - “Sowing Season (Yeah)”
- The Bronx - “Six Days A Week”
- Bush - “Comedown”
- Children Of Bodom - “Done With Everything, Die For Nothing”
- Coldplay - “In My Place”
- Darker My Love - “Blue Day”
- Darkest Hour - “Demon(s)”
- David Bowie - “Fame”
- Deep Purple - “Woman From Tokyo ('99 Remix)”
- Dire Straits - “Sultans Of Swing”
- The Derek Trucks Band - “Younk Funk”
- The Duke Spirit - “Send A Little Love Token”
- Duran Duran - “Hungry Like The Wolf”
- Eagles Of Death Metal - “Wannabe In L.A.”
- Elliott Smith - “L.A.”
- Elton John - “Saturday Night's Alright (For Fighting)”
- Face To Face - “Disconnected”
- Garbage - “Only Happy When It Rains”
- Gorillaz - “Feel Good Inc.”
- Gov't Mule - “Streamline Woman”
- Grand Funk Railroad - “We're An American Band”
- Iggy Pop - “Lust For Life (Live)”
- Iron Maiden - “2 Minutes To Midnight”
- Jeff Beck - “Scatterbrain (Live)”
- Jimmy Eat World - “Bleed American”
- John Mellencamp - “Hurts So Good”
- Johnny Cash - “Ring Of Fire”
- Kaiser Chiefs - “Never Miss A Beat”
- King Crimson - “21st Century Schizoid Man”
- Kings Of Leon - “Sex On Fire”
- Kiss - “Shout It Out Loud”
- Love and Rockets - “Mirror People”
- Megadeth - “Sweating Bullets”
- Mötley Crüe - “Looks That Kill”
- Muse - “Plug In Baby”
- My Morning Jacket - “One Big Holiday”
- Nirvana - “Lithium (Live)”
- Nirvana - “Smells Like Teen Spirit”
- No Doubt - “Ex-Girlfriend”
- Peter Frampton - “Do You Feel Like We Do? (Live)”
- The Police - “So Lonely”
- Public Enemy Featuring Zakk Wylde - “Bring the Noise 20XX”
- Queen & David Bowie - “Under Pressure”
- Queens Of The Stone Age - “Make It Wit Chu”
- Rammstein – “Du Hast”
- The Rolling Stones - “Sympathy For The Devil”
- Rose Hill Drive - “Sneak Out”
- Rush - “The Spirit Of Radio (Live)”
- Santana - “No One To Depend On (Live)”
- Scars On Broadway - “They Say”
- Screaming Trees - “Nearly Lost You”
- Smashing Pumpkins - “Bullet With Butterfly Wings”
- Sonic Youth - “Incinerate”
- Stevie Wonder - “Superstition”
- Spacehog - “In The Meantime”
- Sublime - “What I Got”
- Sunny Day Real Estate - “Seven”
- T. Rex - “20th Century Boy”
- The Killers - “All The Pretty Faces”
- The Raconteurs - “Steady As She Goes”
- The Sword - “Maiden, Mother & Crone”
- Thin Lizzy - “Jailbreak”
- Thrice - “Deadbolt”
- Tom Petty - “Runnin' Down A Dream”
- Tom Petty & The Heartbreakers - “American Girl”
- TV On The Radio - “Wolf Like Me”
- Vampire Weekend - “A-Punk”
- Weezer - “Why Bother?”
- The White Stripes - “Blue Orchid”
- Wild Cherry - “Play That Funky Music”
- Wolfmother - “Back Round”